بررسی‌ تاثیر پلاسمای غنی شده از پلاکت اتولوگ، بر روی موارد عود سینوزیت متعاقب جراحی اندوسکوپیک سینوس

Background:  For many patients with sinonasal polyposis, functional endoscopic sinus surgery (FESS) has provided much needed relief from a condition that, by its daily aggravation, can significantly reduce quality of life. In some patients, however, symptom relief is not achieved even after surgery, or the disease recurs and patients must return for revision surgery .many patients whose symptoms of chronic or recurrent sinusitis persist despite primary FESS and  long-term maximal medical therapy, underwent revision FESS Methods: Prospective, randomized, controlled, clinical trial using an intra patient control design The study enrolled patients with recurrent or persistent polyposis after primary FESS to compare the effect of autologous Platelet-rich plasma (PRP) using an intra patient control design. After local application of PRP, efficacy of this type of treatment was assessed with Endoscopy and Snot-22 questioner PRP was selected because of it’s anti-inflammatory effect. PRP will be put locally in involved sinuses with endoscope guidance and the patient will be re-examined and re-evaluated with standard questionnaire and endoscopy 4 weeks later and 9 months later to assess the effect of this novel treatment option. Results: A total of 16 patients were included in the study. PRP was successfully deployed in all 16 patients. PRP provided symptom relief after the first and ninth month of treatment due to snot-22 questioner.  In seven patients (43.75 percent) the endoscopic grade decreased from +2 to +1 after the first month of treatment Conclusion: This study showed that use of PRP improves patient symptoms according to Snot-22 questioner and endoscopic grading score. There was no correlation between CT-score and response to treatment.